Sr. Scientist/Principal Scientist, AAV Molecular Biologist

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Sr. Scientist/Principal Scientist, AAV Molecular Biologist

Function: Research & Development

Job Title: Sr. Scientist/Principal Scientist, AAV Molecular Biologist

Job Location: Boston


Job Summary

At QLD Biotherapeutics, we develop cell and gene therapies using innovative technologies to treat devastating diseases.  We are seeking a highly motivated individual to join the AAV team, focusing on early drug discovery and technology development.

This position provides an excellent opportunity to work closely with an experienced drug discovery and development team and lead early-stage platform development in a fast-paced and highly collaborative environment.

Primary Responsibilities

  • Design and optimize DNA vector constructs (AAV backbone) to support discovery and preclinical activities.
  • Work with collaborators to identify, design and evaluate minimal cell-specific promoters.
  • Lead the design, optimization, and execution of in vitro assays to validate and characterize novel constructs.
  • Establish in vitro assays to support research activities.
  • Work closely with the Team Lead to plan and execute key studies in-house and at CRO.
  • Oversee AAV production pipeline to ensure program timelines are met
  • Present experimental designs, results and interpretations in group meetings, project team meetings and/or departmental meetings.
  • Maintain detailed records of experiments in the form of electronic lab notebook (eLN) and study reports.


  • D. with 5+ years in molecular biology, virology, biotechnology, or related field in industry settings.
  • Prior experience working with viral vectors, ideally AAV, and knowledge of construct design
  • Proven track record showing proficiency in molecular biology techniques (e.g. molecular cloning, immunoblot, gene transfection procedures).
  • Ability to design and develop new assays, rigorously analyze & interpret data, and efficiently move projects forward.
  • Proficient in mammalian cell culture and aseptic techniques.
  • Identify challenges and seek input from colleagues and supervisor for solutions to diverse problems, and demonstrate motivation in pursuing scientific answers through thorough experimental planning
  • Ability to work under minimal supervision, manage multiple projects, be proactive, team-oriented and collaborative.
  • Prior experience managing junior research associates.
  • Outstanding communication skills.

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